If you decide to go on a road trip from Memphis, these are some blues destinations well worth your time.
Delta Blues Museum

About an hour’s drive south from Memphis, this homespun museum in Clarksdale covers important musicians from the Mississippi Delta like Muddy Waters, Otis Spann, Pinetop Perkins, Charlie Musselwhite, and many more. They have some great displays and artifacts, including the remains of Muddy’s cabin from Stovall Farms where he lived as a sharecropper and tractor driver.
Delta Blues Museum
1 Blues Alley, Clarksdale, MS 38614
Phone: (662) 627-6820
http://www.deltabluesmuseum.org/high/index.asp
Ground Zero Club
Also in Clarksdale, MS, the club owned by Morgan Freeman showcases modern blues musicians. You might see him when he’s between movies and back in his home town.

Ground Zero Club
252 Delta Ave, Clarksdale, MS 38614
Phone: +1 662-621-9009
http://www.groundzerobluesclub.com/
If you are driving south to New Orleans, the two cities are about 800 miles apart. You can motor through Mississippi along the Blues Trail and see many historic blues landmarks and museums along the Mississippi Delta.
Along the Blues Trail, the impressive B.B. King Museum in Indianola, MS is a shrine for blues lovers.
http://www.bbkingmuseum.org/

Mississippi Blues Trail – MDA Tourism
P.O. Box 849, Jackson, MS 39205
Phone: (601) 359-3449
http://msbluestrail.org/